1) Study Resume and Prepare Questionnaire
The applicant's resume should be reviewed keeping in mind the job description and job specification.
Next, prepare a standardized set of questions you want to ask the applicant.
Avoid asking bipolar questions where the applicant can answer from two choices.

2) Ease the candidate
The applicant may be tensed and nervous. If you want to know the candidate thoroughly try to ease the candidate. Begin the interview session with some simple questions.
Once the candidate is relaxed you can give a brief about the company.

3) Questioning the candidate
The questions prepared in the first step will guide you here. Additional questions can be from the answers to your standard questions.
Adopt a policy of not to talk too much. After the applicant has answered your question pause for a second. This will encourage the candidate to continue talking.

4) Concluding session
As soon as the questioning is over ask the candidate if he/ she has any question or clarification they want about the company or the job applied for.
Make notes about the interview while it is fresh in your mind, and take time to assess the applicant's responses after the applicant leaves.